1H-imidazole-2-carbaldehyde → (RS)-5-Chloro-1-(1H-imidazol-2-ylmethyl)-2-methyl-2,3-dihydro-1H-indole
반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]([CH3:11])[CH2:5]2.[NH:12]1[CH:16]=[CH:15][N:14]=[C:13]1[CH:17]=O.C([BH3-])#N.[Na+]>CO.[Cl-].[Zn+2].[Cl-]>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:17][C:13]1[NH:12][CH:16]=[CH:15][N:14]=1)[CH:6]([CH3:11])[CH2:5]2참가 물질
6
실험 절차
Prepared analogously to Example 1, from 5-chloro-2-methyl-2,3-dihydro-1H-indole, imidazole-2-carboxaldehyde, zinc chloride and sodium cyanoborohydride in methanol. MS (ISP): 250.1 ([{37Cl}M+H]+), 248.2 ([{35Cl}M+H]+).
출처 및 근거
- ORD 기록
- ord-c0ba9ad74fbc4fe3867189831552b0ac
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07834044B2
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