7-Aminoindole → HCID 178527228, 화합물

HRID 1173093

반응식

HRID 1173093 반응식
[S:1]([C:5]1[CH:10]=[CH:9][C:8]([S:11](Cl)(=[O:13])=O)=[CH:7][CH:6]=1)(=[O:4])(=[O:3])[NH2:2].N[C:16]1[CH:17]=[CH:18][CH:19]=[C:20]2[C:24]=1[NH:23][CH:22]=[CH:21]2>>[NH:23]1[C:24]2[C:20](=[CH:19][CH:18]=[CH:17][C:16]=2[NH:2][S:1]([C:5]2[CH:6]=[CH:7][C:8]([SH:11]=[O:13])=[CH:9][CH:10]=2)(=[O:3])=[O:4])[CH:21]=[CH:22]1

참가 물질

3

반응물 2

HCID 1116347-AminoindoleHCID 109561594-Sulfamoylbenzene-1-sulfonyl chloride

생성물 1

HCID 178527228HCID 178527228, 화합물수율 69.4%

실험 절차

767 mg (3.0 mmol) of 4-sulfamoylbenzenesulfonyl chloride was reacted with 264 mg (2.0 mmol) of 7-amino-1H-indole and treated, to give 445 mg of N-(1H-indole-7-yl)-4-sulfanoylbenzenesulfonamide. The resulting compound was chlorinated using N-chlorosuccinimide in dichloromethane, to give 349 mg of the title compound.

후처리

  1. additiontreated

출처 및 근거

ORD 기록
ord-d24f49b68bf944d79c2e8a820fc732a0
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834049B2

연결된 노트

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