Potassium Carbonate → 1-Chloroisoquinolin-6-amine

HRID 1173121노트

반응식

HRID 1173121 반응식
[Cl:1][C:2]1[C:11]2[C:6](=[CH:7][C:8]([NH:12]S(C3C=CC(C)=CC=3)(=O)=O)=[CH:9][CH:10]=2)[CH:5]=[CH:4][N:3]=1.[OH-].[Na+].C(=O)([O-])[O-].[K+].[K+]>S(=O)(=O)(O)O>[NH2:12][C:8]1[CH:7]=[C:6]2[C:11](=[CH:10][CH:9]=1)[C:2]([Cl:1])=[N:3][CH:4]=[CH:5]2

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 14798Sodium HydroxideHCID 22674092HCID 22674092, 화합물

생성물 1

HCID 226741141-Chloroisoquinolin-6-amine수율 76.81%

시약·촉매·용매 1

HCID 1118Sulfuric Acid용매

실험 절차

1-Chloro-6-(4-toluenesulfonylamino) isoquinoline (3.323 g, Production Example 22b) was dissolved in sulfuric acid (30 ml), followed by stirring at room temperature overnight. The reaction solution was poured into ice, and basified by adding an aqueous sodium hydroxide solution and then potassium carbonate thereto, followed by extracting with ethyl acetate. The extract was washed with brine and dried over anhydrous magnesium sulfate. The solvent was evaporated, to give the title compound (1.37 g, 76.81%) as yellowish brown crystals.

후처리

  1. additionThe reaction solution was poured into ice
  2. extractionby extracting with ethyl acetate
  3. washThe extract was washed with brine
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customThe solvent was evaporated

출처 및 근거

ORD 기록
ord-5b16ce11584f41a5b86faf34f50bfe80
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834049B2

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