Hydrochloric Acid → 2-(Aminomethyl)-3,5-di-tert-butylphenol hydrochloride

HRID 1173301

반응식

HRID 1173301 반응식
Cl.[Cl:2]CC([NH:6][CH2:7][C:8]1[C:13]([OH:14])=[CH:12][C:11]([C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:10][C:9]=1[C:19]([CH3:22])([CH3:21])[CH3:20])=O>C(O)C>[ClH:2].[NH2:6][CH2:7][C:8]1[C:9]([C:19]([CH3:20])([CH3:21])[CH3:22])=[CH:10][C:11]([C:15]([CH3:18])([CH3:17])[CH3:16])=[CH:12][C:13]=1[OH:14]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 687174522-Chloro-N-(2,4-di-tert-butyl-6-hydroxybenzyl)acetamide

생성물 1

HCID 452597712-(Aminomethyl)-3,5-di-tert-butylphenol hydrochloride

시약·촉매·용매 1

HCID 702Ethanol용매

반응 조건

온도
85 °C

실험 절차

To a solution of 50 mL ethanol and 15 mL conc. hydrochloric acid was added 4.35 g (0.014 mol) of the product of Step A and the reaction mixture was stirred and heated to 85° C. using an external oil bath for 3 h. The reaction mixture was then cooled to room temperature and evaporated in vacuo. Excess water was removed from the product mixture by azeotropic distillation of added portions of toluene on a rotary evaporator. The residue was triturated with ether and dried overnight in vacuo to afford the title compound as a white crystalline solid.

후처리

  1. customfor 3 h
  2. temperatureThe reaction mixture was then cooled to room temperature
  3. customevaporated in vacuo
  4. customExcess water was removed from the product mixture by azeotropic distillation of added portions of toluene on a rotary evaporator
  5. customThe residue was triturated with ether
  6. customdried overnight in vacuo

출처 및 근거

ORD 기록
ord-687d2b360f4f4ee79868c9be6a3d7dff
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07834062B2

연결된 노트

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