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llms.txt · MCP 가이드개인정보처리방침 · 이용약관 · 지원v1.8.0
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Hydrochloric Acid → methyl (1S)-1-[({(1S,3S,4S)-4-amino-1-benzyl-3-hydroxy-5-[4-(6-methoxy-2-pyridinyl)phenyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate

HRID 1174325
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HRID 1174325 반응식
[OH:1][C@@H:2]([CH2:30][C@@H:31]([NH:39][C:40](=[O:51])[C@@H:41]([NH:46][C:47]([O:49][CH3:50])=[O:48])[C:42]([CH3:45])([CH3:44])[CH3:43])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[C@@H:3]([NH:19]C(=O)OCC1C=CC=CC=1)[CH2:4][C:5]1[CH:10]=[CH:9][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[N:12]=2)=[CH:7][CH:6]=1.Cl>CO.[Pd]>[NH2:19][C@@H:3]([CH2:4][C:5]1[CH:6]=[CH:7][C:8]([C:11]2[CH:16]=[CH:15][CH:14]=[C:13]([O:17][CH3:18])[N:12]=2)=[CH:9][CH:10]=1)[C@@H:2]([OH:1])[CH2:30][C@@H:31]([NH:39][C:40]([C@@H:41]([NH:46][C:47](=[O:48])[O:49][CH3:50])[C:42]([CH3:44])([CH3:45])[CH3:43])=[O:51])[CH2:32][C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1
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참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 86726228benzyl (1S,2S,4S)-2-hydroxy-4-({(2S)-2-[(methoxycarbonyl)amino]-3,3-dimethylbutanoyl}amino)-1-[4-(6-methoxy-2-pyridinyl)benzyl]-5-phenylpentylcarbamate

생성물 1

HCID 86726227methyl (1S)-1-[({(1S,3S,4S)-4-amino-1-benzyl-3-hydroxy-5-[4-(6-methoxy-2-pyridinyl)phenyl]pentyl}amino)carbonyl]-2,2-dimethylpropylcarbamate

시약·촉매·용매 2

HCID 23938Palladium촉매
HCID 887
Methanol
용매

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온도
25 °C

실험 절차

A solution containing the product from Example 120A (0.028 g, 0.041 mmol) in methanol (1 mL) was treated with 10% Pd on carbon (0.003 g) and HCl solution (0.030 mL, 4 N in dioxane), and the reaction was stirred under a hydrogen atmosphere (balloon pressure) at 25° C. for 16 hours. The reaction was filtered through a bed of celite and rinsed with methanol. The solvent was concentrated to give the title compound as the hydrochloride salt, which was used without further purification.

후처리

  1. filtrationThe reaction was filtered through a bed of celite and
  2. washrinsed with methanol
  3. concentrationThe solvent was concentrated

출처 및 근거

ORD 기록
ord-44a981a8ef3d438cbfdc1e92725242b6
출처 데이터셋
uspto-grants-2010_11
DOI
10.6084/m9.figshare.5104873.v1
특허 번호
US07834043B2

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