tert-butyl 3-methyl-N-(methylsulfonyl)-L-valinate → (S)-3,3-Dimethyl-2-(methylsulfonamido)butanoic acid

반응식

[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:9]([O:11]C(C)(C)C)=[O:10])[NH:4][S:5]([CH3:8])(=[O:7])=[O:6]>Cl.O1CCOCC1>[CH3:1][C:2]([CH3:17])([CH3:16])[C@@H:3]([C:9]([OH:11])=[O:10])[NH:4][S:5]([CH3:8])(=[O:7])=[O:6]

참가 물질

실험 절차

A solution of Example 152A (59 mg, 0.22 mmol) in 4N HCl in dioxane (1 mL) at 25° C. for 4 h, and the solvents were evaporated to give the crude title compound (49 mg, 100%).

후처리

customthe solvents were evaporated

출처 및 근거

ORD 기록: ord-b2894561c7914198ba750d8652d40cbb
출처 데이터셋: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07834043B2

반응 노트

불러오는 중…

참가 물질

반응물 1

HCID 86599586tert-butyl 3-methyl-N-(methylsulfonyl)-L-valinate

생성물 1

HCID 61142133(S)-3,3-Dimethyl-2-(methylsulfonamido)butanoic acid수율 106.4%

시약·촉매·용매 2

HCID 313Hydrochloric Acid용매

HCID 312751,4-Dioxane용매

실험 절차

A solution of Example 152A (59 mg, 0.22 mmol) in 4N HCl in dioxane (1 mL) at 25° C. for 4 h, and the solvents were evaporated to give the crude title compound (49 mg, 100%).

후처리

customthe solvents were evaporated

출처 및 근거

ORD 기록: ord-b2894561c7914198ba750d8652d40cbb
출처 데이터셋: uspto-grants-2010_11
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07834043B2

반응 노트

불러오는 중…