[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][NH:14][C@H:15]([C:20]([O:22]C(C)(C)C)=[O:21])[C:16]([CH3:19])([CH3:18])[CH3:17])=[O:10])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>Cl.O1CCOCC1>[CH2:1]([O:8][C:9]([NH:11][CH2:12][CH2:13][NH:14][C@H:15]([C:20]([OH:22])=[O:21])[C:16]([CH3:19])([CH3:17])[CH3:18])=[O:10])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1The product from Example 180A (0.870 mmol) was dissolved in an HCl solution in dioxane (5.0 mL, 4 N), and the mixture was stirred at room temperature for 12 hours. The solvent was evaporated to afford the title compound as the hydrochloride salt. The residue was used without further purification.
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