Hydrochloric Acid → 3-(2-Ethoxyethoxy)propanenitrile

To an ice-water cooled mixture of 2-ethoxyethanol (1 g, 11.1 mmol) and Triton B (40% in MeOH, 0.138 g, 0.33 mmol) was added acrylonitrile (0.618 g, 11.6 mmol). The mixture was stirred at room temperature for 24 hours. It was then neutralized with 0.1 M HCl (3.3 cm3) and extracted with CH2Cl2 (2×10 cm3). The extracts were concentrated under reduced pressure and the residue was Kugelrohr-distilled to give the product 3-(2-ethoxyethoxy)propanenitrile (1.20 g, 75.5%) as a colourless oil, bp 100-130° C./20 Torr.

1. extractionextracted with CH2Cl2 (2×10 cm3)
2. concentrationThe extracts were concentrated under reduced pressure
3. distillationthe residue was Kugelrohr-distilled

ORD 기록

ord-7c95205830064096887ee435af8e85c8

출처 데이터셋

uspto-grants-2010_11

DOI

10.6084/m9.figshare.5104873.v1

특허 번호

US07838483B2