Methanol → Methyl D-arabinofuranoside
반응식
[O:1]=[CH:2][C@H:3]([C@@H:5]([C@@H:7]([CH2:9][OH:10])[OH:8])[OH:6])[OH:4].[CH3:11]O>Cl>[O:1]([CH3:11])[CH:2]1[O:8][C@H:7]([CH2:9][OH:10])[C@@H:5]([OH:6])[C@@H:3]1[OH:4]참가 물질
4
실험 절차
D-Arabinose (1, 25 g, 167 mmol) was stirred for 5 hours in 0.5% hydrogen chloride in methanol (675 mL) at room temperature and then neutralized with Amberlite IRA-400 OH anion exchange resin. The filtrate and washings were combined and evaporated to dryness and the crude product was purified by silica gel chromatography (CHCl3/MeOH, 92:8) to afford 26.2 g of methyl D-arabinofuranoside (2, 95% yield) as an and (1:1) mixture. MS 164 (M)+.
후처리
- customevaporated to dryness
- customthe crude product was purified by silica gel chromatography (CHCl3/MeOH, 92:8)
출처 및 근거
- ORD 기록
- ord-ece92f3ab9c34554a218dd65b517bc9e
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07838508B2
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