Ammonium formate → 2-Methyloctahydropyrrolo(3,4-c)pyrrole

HRID 1174699노트

반응식

HRID 1174699 반응식
[CH2:1]([N:8]1[CH2:15][CH:14]2[CH:10]([CH2:11][N:12](C)[CH2:13]2)[CH2:9]1)C1C=CC=CC=1.C([O-])=O.[NH4+]>CO.[Pd]>[CH3:1][N:8]1[CH2:15][CH:14]2[CH:10]([CH2:11][NH:12][CH2:13]2)[CH2:9]1

참가 물질

5

반응물 2

HCID 2723923Ammonium formateHCID 129585342-Benzyl-5-methyloctahydropyrrolo[3,4-c]pyrrole

생성물 1

HCID 129585332-Methyloctahydropyrrolo(3,4-c)pyrrole

시약·촉매·용매 2

HCID 23938Palladium촉매HCID 887Methanol용매

실험 절차

A solution of 2-benzyl-5-methyloctahydropyrrolo[3,4-c]pyrrole (2.4 g) in methanol (60 ml) was mixed with ammonium formate (2.1 g) and palladium on carbon (5%, 0.12 g), and the mixture was refluxed for 8 hours. After cooling, the reaction solution was filtered and concentrated. The crude product could be directly reacted further. The product with the molecular weight of 126.20 (C7H14N2); MS (ESI): 127 (M+H+) was obtained in this way.

후처리

  1. temperaturethe mixture was refluxed for 8 hours
  2. temperatureAfter cooling
  3. filtrationthe reaction solution was filtered
  4. concentrationconcentrated
  5. customThe crude product could be directly reacted further
  6. customMS (ESI): 127 (M+H+) was obtained in this way

출처 및 근거

ORD 기록
ord-acd9209c378d4023ba6e4dd1e5c6a91f
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07838547B2

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