Methylamine → N-Methyl-6-nitrobenzo[D]thiazol-2-amine

HRID 1174960

반응식

HRID 1174960 반응식
Cl[C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1.[CH3:14][NH2:15]>C1COCC1.O>[CH3:14][NH:15][C:2]1[S:3][C:4]2[CH:10]=[C:9]([N+:11]([O-:13])=[O:12])[CH:8]=[CH:7][C:5]=2[N:6]=1

참가 물질

5

반응물 2

HCID 6329MethylamineHCID 754762-Chloro-6-nitrobenzothiazole

생성물 1

HCID 638568N-Methyl-6-nitrobenzo[D]thiazol-2-amine수율 88%

시약·촉매·용매 2

HCID 962Water용매HCID 8028Tetrahydrofuran용매

실험 절차

Place 2-chloro-6-nitro-benzothiazole (5.82 g, 27.1 mmol) in THF (130 mL). Add 40% methylamine in water (7 mL) and stir until the product precipitates out. Concentrate in vacuo and then triturate with methanol. Filter off the product and wash with methanol, Dry thoroughly to yield 4.99 g (88%) of the title compound: mass spectrum (ion-spray): (m/z)=210.0 (M+1).

후처리

  1. customprecipitates out
  2. concentrationConcentrate in vacuo
  3. customtriturate with methanol
  4. filtrationFilter off the product
  5. washwash with methanol
  6. customDry thoroughly

출처 및 근거

ORD 기록
ord-d63f6ac0ae0d46888a58e608370ee763
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07838543B2

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