4-Bromobiphenyl → 4-BROMO-4'-SULFOBIPHENYL

HRID 1175080노트

반응식

HRID 1175080 반응식
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.Cl[S:15]([OH:18])(=[O:17])=[O:16]>C(Cl)(Cl)Cl>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:15]([OH:18])(=[O:17])=[O:16])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

참가 물질

4

반응물 2

HCID 71014-BromobiphenylHCID 24638Chlorosulfonic acid

생성물 1

HCID 45247074-BROMO-4'-SULFOBIPHENYL수율 92%

시약·촉매·용매 1

HCID 6212Chloroform용매

실험 절차

A 500 mL round-bottom-flask equipped with an addition funnel, stirring bar, and gas inlet was charged with 4-bromo-biphenyl (50 g, 0.215 mol) and chloroform (200 mL) then purged with nitrogen. Chlorosulfonic acid (18 mL, 0.27 mol) was added dropwise to the solution from the addition funnel then stirred for 1 hour. The resulting precipitate was collected by vacuum filtration, washed with cold chloroform, and dried under vacuum to give 61.97 g of 4′-bromo-biphenyl-4-sulfonic acid (92% yield).

후처리

  1. customA 500 mL round-bottom-flask equipped with an addition funnel
  2. customthen purged with nitrogen
  3. stirringthen stirred for 1 hour
  4. filtrationThe resulting precipitate was collected by vacuum filtration
  5. washwashed with cold chloroform
  6. customdried under vacuum

출처 및 근거

ORD 기록
ord-044e38433a9142c5936bba0e23712c87
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07838612B2

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