1-tert-Butyl 3-ethyl 3-cyanoazetidine-1,3-dicarboxylate → 1-Tert-butyl 3-methyl 3-(aminomethyl)azetidine-1,3-dicarboxylate
반응식
[CH2:1]([O:3][C:4]([C:6]1([C:17]#[N:18])[CH2:9][N:8]([C:10]([O:12][C:13]([CH3:16])([CH3:15])[CH3:14])=[O:11])[CH2:7]1)=[O:5])C.[H][H]>CO.[Ni]>[CH3:1][O:3][C:4]([C:6]1([CH2:17][NH2:18])[CH2:9][N:8]([C:10]([O:12][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:11])[CH2:7]1)=[O:5]참가 물질
5
실험 절차
3-Cyano-azetidine-1,3-dicarboxylic acid 1-tert-butyl ester 3-ethyl ester (7.75 g; 30.5 mmol) in methanol (1000 ml) is combined with wet RaNi (˜28 g) and hydrogenated at room temperature under 1 atm of hydrogen for 2 hours. The reaction mixture is filtered and evaporated to dryness to yield the title compound as light brown resin, which crystallizes slowly (6.8 g; 91%).
후처리
- filtrationThe reaction mixture is filtered
- customevaporated to dryness
출처 및 근거
- ORD 기록
- ord-378a6e0e38bf434db0c6f29381c8ff71
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07838674B2
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