Benzyl isocyanate → HCID 178418694, 화합물

HRID 11756

반응식

HRID 11756 반응식
[O:1]1[CH:5]=[CH:4][CH:3]=[C:2]1[C:6]1[N:11]=[C:10]([NH2:12])[NH:9][C:8]2=[N:13][CH:14]=[CH:15][C:7]=12.[CH2:16]([N:23]=[C:24]=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C1COCC1>[CH2:16]([NH:23][C:24]([NH:12][C:10]1[NH:9][C:8]2=[N:13][CH:14]=[CH:15][C:7]2=[C:6]([C:2]2[O:1][CH:5]=[CH:4][CH:3]=2)[N:11]=1)=[O:25])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1

참가 물질

4

반응물 2

HCID 76639Benzyl isocyanateHCID 178419058HCID 178419058, 화합물

생성물 1

HCID 178418694HCID 178418694, 화합물수율 19.1%

시약·촉매·용매 1

HCID 8028Tetrahydrofuran용매

실험 절차

A solution of 4-(2-furyl)-1H-pyrrolo[2,3-d]pyrimidine-2-amine (192 mg, 0.96 mmol) in THF (3 mL) was treated with benzyl isocyanate (118 μL, 0.96 mmol), stirred at room temperature for 16 h and the resulting solid filtered and washed with EtOAc to give the title compound (61 mg, 19%) as a yellow solid.

후처리

  1. filtrationthe resulting solid filtered
  2. washwashed with EtOAc

출처 및 근거

ORD 기록
ord-e3a6e51d909246489019c19083530959
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098333B2

연결된 노트

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