Iodoethane → 3-Bromo-5-(methoxymethyl)pyridine

HRID 1175606노트

반응식

HRID 1175606 반응식
[CH3:1][O:2][C:3](=O)[C:4]1[CH:9]=[C:8]([Br:10])[CH:7]=[N:6][CH:5]=1.ICC>>[Br:10][C:8]1[CH:7]=[N:6][CH:5]=[C:4]([CH2:3][O:2][CH3:1])[CH:9]=1

참가 물질

3

반응물 2

HCID 6340IodoethaneHCID 699336Methyl 5-bromopyridine-3-carboxylate

생성물 1

HCID 186245693-Bromo-5-(methoxymethyl)pyridine수율 89%

실험 절차

Prepared in a similar manner to Example 26a starting from (5-bromopyridin-3-yl)methanol (example 26d) and iodoethane. Yield: 89%. 1H NMR (400 MHz, CDCl3): δ 3.43 (s, 3H), 4.46 (s, 2H), 7.85 (s, 1H), 8.47 (s, 1H), 8.61 (s, 1H).

후처리

  1. customPrepared in a similar manner to Example 26a

출처 및 근거

ORD 기록
ord-154659c0d825404ba641e6ff01cac9ab
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842324B2

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