Dimethylformamide → HCID 66746413, 화합물

HRID 1175755노트

반응식

HRID 1175755 반응식
[C:1]12([CH2:9][CH:8](NC(NC3SC4C=C(F)C=CC=4N=3)=O)[C:7]3[CH:24]=[CH:25][CH:26]=[CH:27][C:6]=3[O:5]1)[CH2:4][CH2:3][CH2:2]2.IC.[C:30](=O)([O-])[O-:31].[K+].[K+].CN(C)C=[O:39]>>[CH3:30][O:31][C:25]1[CH:26]=[CH:27][C:6]2[O:5][C:1]3([CH2:2][CH2:3][CH2:4]3)[CH2:9][C:8](=[O:39])[C:7]=2[CH:24]=1

참가 물질

5

반응물 4

HCID 6228DimethylformamideHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 16123262HCID 16123262, 화합물

생성물 1

HCID 66746413HCID 66746413, 화합물

실험 절차

To a solution of 3,4-Dihydro-6-hydroxy-4-oxo-spiro[2H-1-benzopyran-2,1′-cyclobutane] (Example 12) (10 mmol) in dimethylformamide, iodomethane (12 mmol) and potassium carbonate (12 mmol) was added and the reaction mixture was stirred at rt for 12 h. Solvent was then evaporated and the residue was dissolved in ethyl acetate. Organic layer was washed with water, brine and separated. It was then dried on anhydrous Na2SO4 and concentrated to afford the desired product as oil.

후처리

  1. customSolvent was then evaporated
  2. dissolutionthe residue was dissolved in ethyl acetate
  3. washOrganic layer was washed with water, brine
  4. customseparated
  5. dry with materialIt was then dried on anhydrous Na2SO4
  6. concentrationconcentrated

출처 및 근거

ORD 기록
ord-0b76445fcbd04a59b47089533712d3f0
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842703B2

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