Sodium borohydride → 6-Chloro-3,4-dihydro-4-hydroxy-spiro[2H-1-benzopyran-2,1'-cyclobutane]
반응식
[BH4-].[Na+].[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[O:15][C:11]3([CH2:14][CH2:13][CH2:12]3)[CH2:10][C:9](=[O:16])[C:8]=2[CH:17]=1>CO>[Cl:3][C:4]1[CH:5]=[CH:6][C:7]2[O:15][C:11]3([CH2:12][CH2:13][CH2:14]3)[CH2:10][CH:9]([OH:16])[C:8]=2[CH:17]=1참가 물질
4
반응 조건
- 온도
- 0 °C
실험 절차
Sodium borohydride (40 mmol) was added to a solution of 6-Chloro-3,4-dihydro-4-oxo-spiro[2H-1-benzopyran-2,1′-cyclobutane] (10 mmol) in methanol (10 ml). at about 0° C. and the reaction mixture was stirred at room temperature for about 2 h and compound was extracted in ethyl acetate. Organic layer was washed with water, brine and separated. It was then dried on anhydrous sodium sulfate and concentrated to afford the desired product as a white solid.
후처리
- extractioncompound was extracted in ethyl acetate
- washOrganic layer was washed with water, brine
- customseparated
- dry with materialIt was then dried on anhydrous sodium sulfate
- concentrationconcentrated
출처 및 근거
- ORD 기록
- ord-83e3f64ff7d3473c9a4e37f6fbdd4e0d
- 출처 데이터셋
- uspto-grants-2010_11
- 특허 번호
- US07842703B2
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