2-Chloromethyl 2-(trimethylsilyl)ethyl ether → HCID 68502641, 화합물

HRID 1176546

반응식

HRID 1176546 반응식
[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1[NH:7][C:8]2[C:14]([C:15]([O:17][CH3:18])=[O:16])=[CH:13][CH:12]=[CH:11][C:9]=2[N:10]=1.Cl[CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25]>>[CH3:1][O:2][CH2:3][CH2:4][CH2:5][C:6]1[N:10]([CH2:20][O:21][CH2:22][CH2:23][Si:24]([CH3:27])([CH3:26])[CH3:25])[C:9]2[CH:11]=[CH:12][CH:13]=[C:14]([C:15]([O:17][CH3:18])=[O:16])[C:8]=2[N:7]=1

참가 물질

3

반응물 2

HCID 27242712-Chloromethyl 2-(trimethylsilyl)ethyl etherHCID 178494907HCID 178494907, 화합물

생성물 1

HCID 68502641HCID 68502641, 화합물

실험 절차

Analogously to Example 228e, 4.3 g of methyl 2-(3-methoxypropyl)-3H-benzoimidazole-4-carboxylate and 3.54 ml of (2-chloromethoxyethyl)trimethylsilane are reacted. The title compound is obtained as a brown solid. Rf=0.33 (95:5 dichloromethane-methanol); Rt=4.26.

출처 및 근거

ORD 기록
ord-f5e0bfe3e4884d15a1af62f0d51bd9a5
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842688B2

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