1,2,3-Benzothiadiazole → 3-Methyl-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzonitrile

HRID 1177473

반응식

HRID 1177473 반응식
[C:1]1([C:7]2([C:10]3[N:15]=[C:14]4[S:16][CH:17]=[N:18][C:13]4=[CH:12][CH:11]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.Br[C:20]1[CH:27]=[CH:26][C:23]([C:24]#[N:25])=[CH:22][C:21]=1[CH3:28].S1C2C=CC=CC=2N=N1>>[CH3:28][C:21]1[CH:22]=[C:23]([CH:26]=[CH:27][C:20]=1[C:17]1[S:16][C:14]2[C:13]([N:18]=1)=[CH:12][CH:11]=[C:10]([C:7]1([C:1]3[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=3)[CH2:8][CH2:9]1)[N:15]=2)[C:24]#[N:25]

참가 물질

4

반응물 3

HCID 675051,2,3-BenzothiadiazoleHCID 27374944-Bromo-3-methylbenzonitrileHCID 591748745-(1-Phenylcyclopropyl)thiazolo[5,4-b]pyridine

생성물 1

HCID 671116823-Methyl-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzonitrile

실험 절차

3-Methyl-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine-2-yl)benzonitrile was synthesized from 5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridine (48.3 mg, 191 μmol) and 4-bromo-3-methylbenzonitrile (45.0 mg, 230 μmol) according to Reference T and the general procedure for azabenzothiazole 2-arylation as a light yellow solid. MS (ESI) m/z: Calculated: 367.1; Observed: 368.1 (M++1).

출처 및 근거

ORD 기록
ord-1e3cbe31eb4f44c8a91e1022abf70cea
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842685B2

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