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Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
HRID 1177579생성일: 2026년 10월 26일

Methyl 1-aminocyclopropane-1-carboxylate hydrochloride → Methyl 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)benzylamino)-cyclopropanecarboxylate

https://huagongshe.com/reaction/1177579

반응식

참여 물질

역할이름HCID투입량
반응물Methyl 1-aminocyclopropane-1-carboxylate hydrochlorideHCID 12760695—
반응물3-Fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehydeHCID 59174907—
생성물Methyl 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)benzylamino)-cyclopropanecarboxylateHCID 67112085—

반응 단계

Reaction of 3-fluoro-4-(5-(1-phenylcyclopropyl)thiazolo[5,4-b]pyridin-2-yl)benzaldehyde (98.0 mg, 0.262 mmol) and methyl 1-aminocyclopropanecarboxylate hydrochloride (40 mg, 0.262 mmol) according to Reference R and the general procedure for reductive amination to give methyl 1-(3-fluoro-4-(5-(1-phenylcyclopropyl)-thiazolo[5,4-b]pyridin-2-yl)benzylamino)-cyclopropanecarboxylate as a tan solid. MS (ESI) m/z: Calculated: 473.2; Observed: 474.1 (M++1).

출처 및 근거

DOI10.6084/m9.figshare.5104873.v1
특허 번호US07842685B2
출처 데이터셋uspto-grants-2010_11
ORD IDord-73f378535c33493a9cc857bc52d11184
출처 메모uspto-grants-2010_11