Hydrogen Bromide → 1-(Bromomethyl)-2-(trifluoromethyl)benzene

HRID 1178015

반응식

HRID 1178015 반응식
[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5]O.[BrH:13]>O>[F:1][C:2]([F:12])([F:11])[C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH2:5][Br:13]

참가 물질

4

반응물 2

HCID 260Hydrogen BromideHCID 676662-(Trifluoromethyl)benzylic alcohol

생성물 1

HCID 1230571-(Bromomethyl)-2-(trifluoromethyl)benzene

시약·촉매·용매 1

HCID 962Water용매

실험 절차

A solution of 2-trifluoromethyl benzyl alcohol (1 g, 5.67 mmol) in aqueous HBr (6 mL) was stirred at 50° C. for 4 hrs. The reaction mixture was diluted with cold water and the product extracted with ethyl acetate. The organic layer was washed with saturated brine solution, dried over sodium sulphate and concentrated to afford 780 mg of 2-trifluoromethylbenzyl bromide.

후처리

  1. extractionthe product extracted with ethyl acetate
  2. washThe organic layer was washed with saturated brine solution
  3. dry with materialdried over sodium sulphate
  4. concentrationconcentrated

출처 및 근거

ORD 기록
ord-de488eae72364be98e4a6cd3d7e791fe
출처 데이터셋
uspto-grants-2010_11
특허 번호
US07842696B2

연결된 노트

불러오는 중…