Potassium Carbonate → 2-(1,4,7,10,13-Pentaoxa-16-azacyclooctadecan-16-yl)ethyl benzoate

HRID 1178183

반응식

HRID 1178183 반응식
[CH2:1]1[NH:18][CH2:17][CH2:16][O:15][CH2:14][CH2:13][O:12][CH2:11][CH2:10][O:9][CH2:8][CH2:7][O:6][CH2:5][CH2:4][O:3][CH2:2]1.[C:19]([O:27][CH2:28][CH2:29]Cl)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1.C(=O)([O-])[O-].[K+].[K+]>CN(C)C=O>[C:19]([O:27][CH2:28][CH2:29][N:18]1[CH2:1][CH2:2][O:3][CH2:4][CH2:5][O:6][CH2:7][CH2:8][O:9][CH2:10][CH2:11][O:12][CH2:13][CH2:14][O:15][CH2:16][CH2:17]1)(=[O:26])[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1

참가 물질

5

반응물 3

HCID 11430Potassium CarbonateHCID 959522-ChloroethylbenzoateHCID 1185781,4,7,10,13-Pentaoxa-16-azacyclooctadecane

생성물 1

HCID 589744672-(1,4,7,10,13-Pentaoxa-16-azacyclooctadecan-16-yl)ethyl benzoate수율 778.6%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
80 °C

실험 절차

A mixture of 26.3 g of 1-aza-18-crown-6, 19.9 g of 2-chloroethyl benzoate, 21.0 g of potassium carbonate, and 60 g of N,N-dimethylformamide was stirred for 10 hours at 80° C. The reaction mixture was subjected to conventional aqueous work-up and purification by column chromatography. There was obtained 320 g of 2-(1,4,7,10,13-pentaoxa-16-azacyclo-octadecan-16-yl)ethyl benzoate (yield 75%).

후처리

  1. customThe reaction mixture was subjected to conventional aqueous work-up and purification by column chromatography

출처 및 근거

ORD 기록
ord-b4693368965a4bfe9517c4f333076d06
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07276324B2

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