Sodium Dithionite → 6-Ethoxypyrimidine-2,4,5-triamine

HRID 1178219노트

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HRID 1178219 반응식
[N:1]([C:3]1[C:4]([O:11][CH2:12][CH3:13])=[N:5][C:6]([NH2:10])=[N:7][C:8]=1[NH2:9])=O.S(S([O-])=O)([O-])=O.[Na+].[Na+]>O>[NH2:10][C:6]1[N:5]=[C:4]([O:11][CH2:12][CH3:13])[C:3]([NH2:1])=[C:8]([NH2:9])[N:7]=1

참가 물질

4

반응물 2

HCID 24489Sodium Dithionite2회HCID 2272506-Ethoxy-5-nitrosopyrimidine-2,4-diamine

생성물 1

HCID 135414226-Ethoxypyrimidine-2,4,5-triamine수율 61.1%

시약·촉매·용매 1

HCID 962Water용매

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온도
60 °C

실험 절차

To a suspension of the compound of example 56 (7.12 g, 38.9 mmoles) in water (150 ml) at 60° C. was added sodium dithionite (46.7 mmol, 8.12 g). Additional sodium dithionite was added till the pink colour completely disappeared and a yellow solution was formed. The solution was stirred at 60° C. for another 4 hours. Water was evaporated and the resulting residue was precipitated from a small amount of water, providing the title compound as a yellow powder (4.02 g, yield 61%). Spectral data are identical with literature data (W. Pfleiderer et al. cited supra).

후처리

  1. customa yellow solution was formed
  2. customWater was evaporated
  3. customthe resulting residue was precipitated from a small amount of water

출처 및 근거

ORD 기록
ord-7a1697465ee144b1a95c620d604bc5ff
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07276506B2

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