Hydrochloric Acid → 3-Amino-3,4-dihydro-1,5-naphthyridin-2(1h)-one dihydrochloride

HRID 1178447노트

반응식

HRID 1178447 반응식
[Cl:1]C1SC2[NH:6][C:7]([C:9]([NH:11][CH:12]3[CH2:21][C:20]4[C:15](=CC=CC=4)[N:14](CCOC)[C:13]3=O)=[O:10])=[CH:8]C=2C=1.[ClH:28]>C(Cl)Cl.O1CCOCC1>[ClH:1].[ClH:28].[NH2:6][CH:7]1[CH2:8][C:13]2[C:12](=[CH:21][CH:20]=[CH:15][N:14]=2)[NH:11][C:9]1=[O:10]

참가 물질

5

반응물 2

HCID 313Hydrochloric AcidHCID 102506062-Chloro-N-{1-[2-(methoxy)ethyl]-2-oxo-1,2,3,4-tetrahydroquinolin-3-yl}-6H-thieno[2,3-b]pyrrole-5-carboxamide

생성물 1

HCID 219068583-Amino-3,4-dihydro-1,5-naphthyridin-2(1h)-one dihydrochloride

시약·촉매·용매 2

HCID 6344Dichloromethane용매HCID 312751,4-Dioxane용매

실험 절차

tert-Butyl (2-oxo-1,2,3,4-tetrahydro-1,5-naphthyridine-3-yl)carbamate (Method 26, 263 mg, 1 mmol) was dissolved in DCM (10 mL) and treated with 4M HCl in dioxan (10 mL). After stirring at ambient temperature for 30 mins. the reaction mixture was evaporated under reduced pressure and the residue triturated with ether (20 mL), to give a white solid which was collected by filtration, washed with ether and dried. (234 mg, 100%).

후처리

  1. customthe reaction mixture was evaporated under reduced pressure
  2. customthe residue triturated with ether (20 mL)
  3. customto give a white solid which
  4. filtrationwas collected by filtration
  5. washwashed with ether
  6. customdried

출처 및 근거

ORD 기록
ord-f143c4c28ca54a0dba4b9dc85fe9bcc9
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07276517B2

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