Hydrogen Peroxide → 1-(2,4-Dichlorophenyl)cyclopropane-1-carboxamide
반응식
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:12]#[N:13])[CH2:11][CH2:10]1.C(=O)([O-])[O-:15].[K+].[K+].OO.O>CS(C)=O>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([C:12]([NH2:13])=[O:15])[CH2:10][CH2:11]1참가 물질
6
반응 조건
- 온도
- 0 °C
실험 절차
1-(2,4-Dichloro-phenyl)-cyclopropanecarbonitrile (2.1 g, 10 mmol) was dissolved in DMSO (10 ml) and the solution cooled to 0° C. using an ice bath. Potassium carbonate (0.2 g, 1.5 mmol) was then added, followed by commercial 30% aqueous hydrogen peroxide (2 mL). The reaction was then allowed to warm to room temperature with stirring over 1 h. Water (20 mL) was added and the 1-(2,4-dichloro-phenyl)-cyclopropanecarboxylic acid amide collected as a white solid. Yield: 2.1 g (90%).
후처리
- temperatureto warm to room temperature
- customthe 1-(2,4-dichloro-phenyl)-cyclopropanecarboxylic acid amide collected as a white solid
출처 및 근거
- ORD 기록
- ord-72b789f8c7c545fe97e9fae1c76b39ff
- 출처 데이터셋
- uspto-grants-2007_10
- 특허 번호
- US07276526B2
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