Dimethyl-(8-thiophen-2-yl-1,4-dioxaspiro[4.5]dec-8-yl)-amine hydrochloride → HCID 12595637, 화합물

HRID 1179063노트

반응식

HRID 1179063 반응식
Cl.[CH3:2][N:3]([CH3:19])[C:4]1([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][C:7]2(OCC[O:8]2)[CH2:6][CH2:5]1>Cl>[CH3:2][N:3]([CH3:19])[C:4]1([C:14]2[S:15][CH:16]=[CH:17][CH:18]=2)[CH2:13][CH2:12][C:7](=[O:8])[CH2:6][CH2:5]1

참가 물질

3

반응물 1

HCID 57475108Dimethyl-(8-thiophen-2-yl-1,4-dioxaspiro[4.5]dec-8-yl)-amine hydrochloride

생성물 1

HCID 12595637HCID 12595637, 화합물

시약·촉매·용매 1

HCID 313Hydrochloric Acid용매

실험 절차

Dimethyl-(8-thiophen-2-yl-1,4-dioxa-spiro[4.5]dec-8-yl)-amine hydrochloride (8.68 g) was dissolved in 7.5M hydrochloric acid (29 ml), stirred for 48 hours at room temperature and then extracted with diethyl ether (2×50 ml). The aqueous phase was rendered alkaline with 5M sodium hydroxide solution, while cooling with ice, extracted with dichloromethane (3×50 ml), dried and concentrated. 4-Dimethylamino-4-thiophen-2-yl-cyclohexanone was obtained as a yellow solid (5.66 g; m.p. 108-110° C.).

후처리

  1. extractionextracted with diethyl ether (2×50 ml)
  2. temperaturewhile cooling with ice
  3. extractionextracted with dichloromethane (3×50 ml)
  4. customdried
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-d0b238ac2e9441afacc492826b34824d
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07276518B2

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