Hydrochloric Acid → Morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide hydrochloride

HRID 1179155노트

반응식

HRID 1179155 반응식
C(OC([N:8]1[CH2:13][CH2:12][C:11]([C:34]#[N:35])([NH:14][C:15](=[O:33])[CH:16]([NH:24][C:25]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[O:26])[CH2:17][CH:18]2[CH2:23][CH2:22][CH2:21][CH2:20][CH2:19]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:36]>O1CCOCC1>[ClH:36].[C:34]([C:11]1([NH:14][C:15]([CH:16]([NH:24][C:25]([N:27]2[CH2:32][CH2:31][O:30][CH2:29][CH2:28]2)=[O:26])[CH2:17][CH:18]2[CH2:19][CH2:20][CH2:21][CH2:22][CH2:23]2)=[O:33])[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]1)#[N:35]

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 694173464-Cyano-4-{3-cyclohexyl-2-[(morpholine-4-carbonyl)-amino]-propionylamino}-piperidine-1-carboxylic acid t-butyl ester

생성물 1

HCID 22260409Morpholine-4-carboxylic acid [1-(4-cyano-piperidin-4-ylcarbamoyl)-2-cyclohexyl-ethyl]-amide hydrochloride

시약·촉매·용매 1

HCID 312751,4-Dioxane용매

실험 절차

4-Cyano-4-{3-cyclohexyl-2-[(morpholine-4-carbonyl)-amino]-propionylamino}-piperidine-1-carboxylic acid t-butyl ester (1000 mg, 2.03 mmol) was dissolved in 20 mL of 4 M HCl in dioxane and stirred for 1 hour at which time the volatiles were remove in vacuo. The resulting residue was triturated with 100 mL of diethyl ether and the resulting solid was collected by filtration under inert atmosphere (the solid is very hygroscopic) and washed 2×50 mL of diethyl ether and dried in vacuo to yield the title compound as a bright white powder (802 mg); MS, m/z 392, M−35).

후처리

  1. customwere remove in vacuo
  2. customThe resulting residue was triturated with 100 mL of diethyl ether
  3. filtrationthe resulting solid was collected by filtration under inert atmosphere (the solid
  4. washwashed 2×50 mL of diethyl ether
  5. customdried in vacuo

출처 및 근거

ORD 기록
ord-1a51d0b032d14746bdea507810aaecba
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279472B2

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