Hydrochloric Acid → 6-Fluoro-2-methyl-5-(1-piperazinyl)quinoline

HRID 1179582노트

반응식

HRID 1179582 반응식
Cl.CC([CH:6]1[CH2:11][N:10]([C:12]2[C:21]([F:22])=[CH:20][CH:19]=[C:18]3[C:13]=2[CH:14]=[CH:15][C:16]([CH3:23])=[N:17]3)[CH2:9][CH2:8][N:7]1C([O-])=O)(C)C>O1CCOCC1>[F:22][C:21]1[C:12]([N:10]2[CH2:9][CH2:8][NH:7][CH2:6][CH2:11]2)=[C:13]2[C:18](=[CH:19][CH:20]=1)[N:17]=[C:16]([CH3:23])[CH:15]=[CH:14]2

참가 물질

4

반응물 2

HCID 313Hydrochloric AcidHCID 866084411,1-Dimethylethyl-4-(6-fluoro-2-methyl-5-quinolinyl)-1-piperazinecarboxylate

생성물 1

HCID 574443146-Fluoro-2-methyl-5-(1-piperazinyl)quinoline수율 156.2%

시약·촉매·용매 1

HCID 312751,4-Dioxane용매2회

실험 절차

A solution of hydrogen chloride in dioxane (4M, 4 mL) was added to a solution of 1,1-dimethylethyl-4-(6-fluoro-2-methyl-5-quinolinyl)-1-piperazinecarboxylate (0.178 g) in dioxane (4 mL) at 0° C. The resulting mixture was warmed to room temperature and stirred for 15 h. The mixture was concentrated in vacuo and partitioned between aqueous sodium hydroxide solution and DCM. The combined organic phases were washed with brine, dried over sodium sulfate and concentrated to afford the title compound (198 mg, 100% yield).

후처리

  1. concentrationThe mixture was concentrated in vacuo
  2. custompartitioned between aqueous sodium hydroxide solution and DCM
  3. washThe combined organic phases were washed with brine
  4. dry with materialdried over sodium sulfate
  5. concentrationconcentrated

출처 및 근거

ORD 기록
ord-5388720d2c374dd4b926c3a58300b1de
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279481B2

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