Benzoic Acid → Rizatriptan Benzoate

HRID 1180101

반응식

HRID 1180101 반응식
[C:1]([OH:9])(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[CH3:10][N:11]([CH2:13][CH2:14][C:15]1[C:19]2[CH:20]=[C:21]([CH2:24][N:25]3[N:29]=[CH:28][N:27]=[CH:26]3)[CH:22]=[CH:23][C:18]=2[NH:17][CH:16]=1)[CH3:12]>C(OC(C)C)(=O)C.C(O)(C)C>[CH3:10][N:11]([CH2:13][CH2:14][C:15]1[C:19]2[CH:20]=[C:21]([CH2:24][N:25]3[N:29]=[CH:28][N:27]=[CH:26]3)[CH:22]=[CH:23][C:18]=2[NH:17][CH:16]=1)[CH3:12].[CH:5]1[CH:4]=[CH:3][C:2]([C:1]([OH:9])=[O:8])=[CH:7][CH:6]=1

참가 물질

5

반응물 2

HCID 243Benzoic AcidHCID 5078Rizatriptan

생성물 1

HCID 77997Rizatriptan Benzoate수율 80.1%

시약·촉매·용매 2

HCID 3776Isopropanol용매HCID 7915Isopropyl Acetate용매

실험 절차

A solution of 147 mg (1.2 mmoles) of benzoic acid in 1 ml of isopropyl acetate was added slowly to a solution of 300 mg (1.1 mmoles) of the rizatriptan base in 2.6 ml of isopropyl alcohol. The mixture was stirred at room temperature for 30 minutes and evaporated to dryness, and the residue recrystallised from ethanol to give 345 mg (80%) of rizatriptan benzoate as a white crystalline solid.

후처리

  1. customevaporated to dryness
  2. customthe residue recrystallised from ethanol

출처 및 근거

ORD 기록
ord-abd210887dcd46259279e7ded4ab972d
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07279581B2

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