Water → N-{[4-(2,3-Butadienyloxy)phenyl]sulfonyl}valine

HRID 1180544노트

반응식

HRID 1180544 반응식
[CH2:1]([O:5][C:6]1[CH:11]=[CH:10][C:9]([S:12]([N:15](C)[CH:16]([CH:21]([CH3:23])[CH3:22])[C:17]([O:19]C)=[O:18])(=[O:14])=[O:13])=[CH:8][CH:7]=1)[CH:2]=[C:3]=[CH2:4].[OH-].[Li+].O>O1CCCC1.CO>[CH2:1]([O:5][C:6]1[CH:7]=[CH:8][C:9]([S:12]([NH:15][C@H:16]([C:17]([OH:19])=[O:18])[CH:21]([CH3:23])[CH3:22])(=[O:13])=[O:14])=[CH:10][CH:11]=1)[CH:2]=[C:3]=[CH2:4]

참가 물질

6

반응물 3

HCID 962WaterHCID 3939Lithium HydroxideHCID 85826253Methyl 2-[{[4-(2,3-butadienyloxy)phenyl]sulfonyl}(methyl)amino]-3-methylbutanoate

생성물 1

HCID 86588656N-{[4-(2,3-Butadienyloxy)phenyl]sulfonyl}valine수율 89.3%

시약·촉매·용매 2

HCID 887Methanol용매HCID 8028Tetrahydrofuran용매

실험 절차

The procedure of Example 12 was followed using the product from Example 14 (300 mg, 0.85 mmol) and lithium hydroxide (41 mg, 1.7 mmol) in tetrahydrofuran (3 ml), methanol (3 ml), and water (1.5 ml) to give 247 mg (86%) of the product.

출처 및 근거

ORD 기록
ord-435ccad00add432985b7c0b7596e1216
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07282496B2

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