Benzoyl chloride → 2-[(2-Benzoylamino-benzyl)-(4-methoxy-benzenesulfonyl)-amino]-acrylic acid methyl ester

HRID 1180557노트

반응식

HRID 1180557 반응식
[NH2:1][C:2]1[CH:27]=[CH:26][CH:25]=[CH:24][C:3]=1[CH2:4][N:5]([S:13]([C:16]1[CH:21]=[CH:20][C:19]([O:22][CH3:23])=[CH:18][CH:17]=1)(=[O:15])=[O:14])[CH:6]([CH2:11]O)[C:7]([O:9][CH3:10])=[O:8].C(N(CC)CC)C.[C:35](Cl)(=[O:42])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1>C(Cl)Cl>[CH3:10][O:9][C:7](=[O:8])[C:6]([N:5]([CH2:4][C:3]1[CH:24]=[CH:25][CH:26]=[CH:27][C:2]=1[NH:1][C:35](=[O:42])[C:36]1[CH:41]=[CH:40][CH:39]=[CH:38][CH:37]=1)[S:13]([C:16]1[CH:17]=[CH:18][C:19]([O:22][CH3:23])=[CH:20][CH:21]=1)(=[O:15])=[O:14])=[CH2:11]

참가 물질

5

반응물 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 18612758Methyl [(2-aminobenzyl)-(4-methoxybenzenesulfonyl)amino]-3-hydroxypropionate

생성물 1

HCID 186130262-[(2-Benzoylamino-benzyl)-(4-methoxy-benzenesulfonyl)-amino]-acrylic acid methyl ester수율 101.8%

시약·촉매·용매 1

HCID 6344Dichloromethane용매

실험 절차

The procedure of Example 33 was followed using the product from Example 32 (500 mg, 1.268 mmol), triethylamine (0.884 ml, 6.34 mmol), and benzoyl chloride (0.324 ml, 2.79 mmol) in methylene chloride (60 ml) to give 620 mg (100%) of the product.

출처 및 근거

ORD 기록
ord-5ae80c2edc15446bbdc25c19353a49a5
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07282496B2

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