1-Phenylpiperazine → [1-({[2-(4-Phenyl-1-piperazinyl)-4-pyrimidinyl]oxy}methyl)cyclobutyl]methanol

HRID 1180780

반응식

Cl[C:2]1[N:7]=[C:6]([O:8][CH2:9][C:10]2([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]2)[CH:5]=[CH:4][N:3]=1.[C:16]1([N:22]2[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1>>[C:16]1([N:22]2[CH2:27][CH2:26][N:25]([C:2]3[N:7]=[C:6]([O:8][CH2:9][C:10]4([CH2:14][OH:15])[CH2:13][CH2:12][CH2:11]4)[CH:5]=[CH:4][N:3]=3)[CH2:24][CH2:23]2)[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1

참가 물질

반응물 2

HCID 70961-Phenylpiperazine

HCID 11413552(1-{[(2-Chloro-4-pyrimidinyl)oxy]methyl}cyclobutyl)methanol

생성물 1

HCID 11439640[1-({[2-(4-Phenyl-1-piperazinyl)-4-pyrimidinyl]oxy}methyl)cyclobutyl]methanol

실험 절차

The title compound was prepared from (1-{[(2-chloro-4-pyrimidinyl)oxy]methyl}cyclobutyl)methanol using the same experimental procedure as in example 21a using 1-phenylpiperazine. 1H NMR (300 MHz, CDCl3) δ 8.01 (d, J=6 Hz, 1H), 7.21 (m, 2H), 6.92-6.82 (m, 3H), 5.93 (d, J=6 Hz, 1H), 4.37 (s, 2H), 3.90 (m, 4H), 3.58 (s, 2H), 3.18 (m, 4H), 2.54 (br s, 1H).

출처 및 근거

ORD 기록: ord-fd6f3ae4733949d3af93f726c52099d6
출처 데이터셋: uspto-grants-2007_10
DOI: 10.6084/m9.figshare.5104873.v1
특허 번호: US07282512B2

연결된 노트

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