Adenine → 9-(Phenylmethyl)-9H-purin-6-amine

HRID 1181195노트

반응식

HRID 1181195 반응식
[N:1]1[C:9]([NH2:10])=[C:8]2[C:4]([N:5]=[CH:6][NH:7]2)=[N:3][CH:2]=1.[H-].[Na+].[CH2:13](Br)[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1>CN(C=O)C>[CH2:13]([N:5]1[CH:6]=[N:7][C:8]2[C:4]1=[N:3][CH:2]=[N:1][C:9]=2[NH2:10])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1

참가 물질

5

반응물 3

HCID 190AdenineHCID 7498Benzyl BromideHCID 24758Sodium hydride

생성물 1

HCID 202629-(Phenylmethyl)-9H-purin-6-amine

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

반응 조건

온도
100 °C

실험 절차

Adenine (1 mmol) in DMF was treated with sodium hydride (1.2 mmol) followed by benzyl bromide (1.2 mmol) at room temperature under nitrogen. The resulting mixture was warmed at 100° C. for 2 h. The cooled reaction mixture was evaporated to dryness. Extraction and chromatography afforded N9-benzyladenine.

후처리

  1. customThe cooled reaction mixture
  2. customwas evaporated to dryness
  3. extractionExtraction and chromatography

출처 및 근거

ORD 기록
ord-a631dcfe8f3941e3912af92044a6d41c
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285543B2

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