Acetic Anhydride → Methyl 3-(formylamino)-2-thiophenecarboxylate

HRID 1181273노트

반응식

HRID 1181273 반응식
[C:1](OC(=O)C)(=[O:3])C.[CH3:8][O:9][C:10]([C:12]1[S:13][CH:14]=[CH:15][C:16]=1[NH2:17])=[O:11]>C(O)=O>[CH3:8][O:9][C:10]([C:12]1[S:13][CH:14]=[CH:15][C:16]=1[NH:17][CH:1]=[O:3])=[O:11]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 89652Methyl 3-amino-2-thiophenecarboxylate

생성물 1

HCID 2777636Methyl 3-(formylamino)-2-thiophenecarboxylate수율 85%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

Formic acid (40 mL) was added to acetic anhydride (60 mL) while cooling in an ice bath. Solid 3-amino-2-thiophenecarboxylic acid methyl ester (77, 10.3 g, 66 mmol) was added to the cold solution in small portions. The cooling bath was removed and the resulting suspension was stirred at room temperature for 4 hours. The reaction mixture was diluted with water (100 mL) and the solid product collected by vacuum filtration to yield 3-(formylamino)-2-thiophenecarboxylic acid methyl ester (10.3 g, 85% yield) as a white solid.

후처리

  1. temperaturewhile cooling in an ice bath
  2. customThe cooling bath was removed
  3. additionThe reaction mixture was diluted with water (100 mL)
  4. filtrationthe solid product collected by vacuum filtration

출처 및 근거

ORD 기록
ord-ed02863559cd41839cd258b368e6d40f
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285556B2

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