Acetic Anhydride → Methyl 3-(formylamino)-2-thiophenecarboxylate

HRID 1181279노트

반응식

HRID 1181279 반응식
[C:1](OC(=O)C)(=[O:3])C.[CH3:8][O:9][C:10]([C:12]1[S:13][CH:14]=[CH:15][C:16]=1[NH2:17])=[O:11]>C(O)=O>[CH3:8][O:9][C:10]([C:12]1[S:13][CH:14]=[CH:15][C:16]=1[NH:17][CH:1]=[O:3])=[O:11]

참가 물질

4

반응물 2

HCID 7918Acetic AnhydrideHCID 89652Methyl 3-amino-2-thiophenecarboxylate

생성물 1

HCID 2777636Methyl 3-(formylamino)-2-thiophenecarboxylate수율 85%

시약·촉매·용매 1

HCID 284Formic Acid용매

실험 절차

Formic acid (40 mL) was added to acetic anhydride (60 mL) while cooling in an ice bath. Solid 3-amino-2-thiophenecarboxylic acid methyl ester (77, 10.3 g, 66 mmol) was added to the cold solution in small portions. The cooling bath was removed and the resulting suspension was stirred at room temperature for 4 hours. The reaction mixture was diluted with water (100 mL) and the solid product collected by vacuum filtration to yield 3-(formylamino)-2-thiophenecarboxylic acid methyl ester (10.3 g, 85% yield) as a white solid.

후처리

  1. temperaturewhile cooling in an ice bath
  2. customThe cooling bath was removed
  3. additionThe reaction mixture was diluted with water (100 mL)
  4. filtrationthe solid product collected by vacuum filtration

출처 및 근거

ORD 기록
ord-490b747be110418d9e46789a51c661f6
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285556B2

반응 노트

불러오는 중…