Water → 1-[2-(Trifluoromethyl)pyrimidin-5-yl]methanamine
반응식
[N:1]([CH2:4][C:5]1[CH:6]=[N:7][C:8]([C:11]([F:14])([F:13])[F:12])=[N:9][CH:10]=1)=[N+]=[N-].C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.O>C1COCC1>[NH2:1][CH2:4][C:5]1[CH:6]=[N:7][C:8]([C:11]([F:14])([F:13])[F:12])=[N:9][CH:10]=1참가 물질
5
실험 절차
To a solution of 5-(azidomethyl)-2-(trifluoromethyl)pyrimidine (Description 120; 660 mg, 3.26 mmol) in anhydrous THF (10 ml) was added triphenylphosphine (1.71 g, 6.52 mmol) and water (0.059 ml, 3.26 mmol) and the resulting mixture stirred at room temperature overnight. The mixture was evaporated and the residue purified by column chromatography on silica elution with 5% MeOH in DCM+0.5% NH4OH to give the title compound (320 mg, 55%) as a pale yellow solid.
후처리
- customThe mixture was evaporated
- customthe residue purified by column chromatography on silica elution with 5% MeOH in DCM+0.5% NH4OH
출처 및 근거
- ORD 기록
- ord-64469a26665d4d448894d148df3eac04
- 출처 데이터셋
- uspto-grants-2007_10
- 특허 번호
- US07285563B2
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