Sodium Bisulfate → 2-(2-trifluoromethyl-phenyl)-3H-pyrido[2,3-d]pyrimidin-4-one

HRID 11817

반응식

HRID 11817 반응식
[F:1][C:2]([F:22])([F:21])[C:3]1[CH:20]=[CH:19][CH:18]=[CH:17][C:4]=1[C:5]([NH:7][C:8]1[N:16]=[CH:15][CH:14]=[CH:13][C:9]=1[C:10]([NH2:12])=[O:11])=O.[O-]CC.[K+].S([O-])(O)(=O)=O.[Na+]>C(O)C.O>[F:1][C:2]([F:22])([F:21])[C:3]1[CH:20]=[CH:19][CH:18]=[CH:17][C:4]=1[C:5]1[NH:12][C:10](=[O:11])[C:9]2[CH:13]=[CH:14][CH:15]=[N:16][C:8]=2[N:7]=1

참가 물질

6

반응물 3

HCID 516919Sodium BisulfateHCID 219392142-[2-(Trifluoromethyl)benzamido]pyridine-3-carboxamideHCID 23670592Potassium ethoxide

생성물 1

HCID 1358508342-(2-trifluoromethyl-phenyl)-3H-pyrido[2,3-d]pyrimidin-4-one

시약·촉매·용매 2

HCID 702Ethanol용매HCID 962Water용매

실험 절차

2-(2-Trifluoromethyl-benzoylamino)-nicotinamide (800 mg, 2.6 mmol) is dissolved in 10 ml of ethanol. Potassium ethoxide (435 mg, 5.2 mmol) is added to the solution which is heated to reflux for 16 h. The reaction mixture is evaporated in vacuo to afford a gummy residue that is dissolved in water and acidified with 10% sodium hydrogen sulfate to pH 7. The resulting precipitate is filtered and dried under vacuum at 50 C to give 2-(2-trifluoromethyl-phenyl)-3H-pyrido[2,3-d]pyrimidin-4-one.

후처리

  1. temperatureis heated
  2. temperatureto reflux for 16 h
  3. customThe reaction mixture is evaporated in vacuo
  4. customto afford a gummy residue that
  5. filtrationThe resulting precipitate is filtered
  6. customdried under vacuum at 50 C

출처 및 근거

ORD 기록
ord-ad07cb21f6bc41b9acab444e1cee39e1
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098330B2

연결된 노트

불러오는 중…