1-Bromo-3-methylbutane → 2-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-7-(3-methylbutyl)-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

HRID 1181767노트

반응식

HRID 1181767 반응식
[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][N:12]1[C:20]([C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=2)=[C:19]2[C:14]([NH:15][C:16](=[O:29])[N:17]([CH3:28])[C:18]2=[O:27])=[N:13]1.Br[CH2:31][CH2:32][CH:33]([CH3:35])[CH3:34].C(=O)([O-])[O-].[K+].[K+]>CN(C=O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:8](=[CH:9][CH:10]=1)[NH:7][CH:6]=[C:5]2[CH2:11][N:12]1[C:20]([C:21]2[N:22]([CH3:26])[CH:23]=[CH:24][N:25]=2)=[C:19]2[C:14]([N:15]([CH2:31][CH2:32][CH:33]([CH3:35])[CH3:34])[C:16](=[O:29])[N:17]([CH3:28])[C:18]2=[O:27])=[N:13]1

참가 물질

5

반응물 3

HCID 78911-Bromo-3-methylbutaneHCID 11430Potassium CarbonateHCID 1363341142-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

생성물 1

HCID 589810922-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-7-(3-methylbutyl)-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

This compound was synthesized by the reaction of 2-[(5-chloro-1H-indol-3-yl)methyl]-5-methyl-3-(1-methyl-1H-imidazol-2-yl)-2H-pyrazolo[3,4-d]pyrimidine-4,6(5H,7H)-dione and 1-bromo-3-methylbutane using potassium carbonate as a base in DMF at 80° C. Mass: 480.16 (M+H).

후처리

  1. customat 80° C

출처 및 근거

ORD 기록
ord-c38e935d2ebc4e0bbcf9cda77a833414
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285558B2

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