Pyrrolidine → HCID 58980628, 화합물

HRID 1181923노트

반응식

HRID 1181923 반응식
[C:1]([CH:5]([CH:8]=O)[CH:6]=O)([CH3:4])([CH3:3])[CH3:2].[CH3:10][NH:11][C:12](=[O:17])[CH2:13][N+:14]([O-:16])=[O:15].N1CCCC1>C(O)C>[C:1]([C:5]1[CH:6]=[C:13]([N+:14]([O-:16])=[O:15])[C:12](=[O:17])[N:11]([CH3:10])[CH:8]=1)([CH3:2])([CH3:3])[CH3:4]

참가 물질

5

반응물 3

HCID 31268PyrrolidineHCID 574612tert-ButylpropanedialHCID 12512111N-Methylnitroacetamide

생성물 1

HCID 58980628HCID 58980628, 화합물수율 30%

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To a solution of 2-tert-butyl-malonaldehyde (385 mg, 3.00 mmol) and the above amide (355 mg, 3.00 mmol) dissolved in ethanol (6.0 mL) was added pyrrolidine (63 microL, 0.750 mmol). The mixture was heated at reflux for 18 h and concentrated in vacuo. Purification by silica-gel chromatography (75% ethyl acetate in hexanes) provided 5-tert-butyl-1-methyl-3-nitro-1H-pyridin-2-one (186 mg, 30%) as an orange solid.

후처리

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 18 h
  3. concentrationconcentrated in vacuo
  4. customPurification by silica-gel chromatography (75% ethyl acetate in hexanes)

출처 및 근거

ORD 기록
ord-bd365ee773104fb7a99758448f1a7250
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07285545B2

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