Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Water → 1-(2,6-Bisbenzyloxy-4-methylphenyl)ethanone
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Water | HCID 962 | — |
| 반응물 | Benzyl Bromide | HCID 7498 | — |
| 반응물 | Potassium Carbonate | HCID 11430 | — |
| 반응물 | 3,5-Dihydroxy-4-acetyltoluene | HCID 10419531 | — |
| 용매 | Dimethylformamide | HCID 6228 | — |
| 용매 | Ethyl Acetate | HCID 8857 | — |
| 생성물 | 1-(2,6-Bisbenzyloxy-4-methylphenyl)ethanone | HCID 22016645 | 79.9% |
반응 단계
1.62 g (9.75 mmol) of 1-(2,6-dihydroxy-4-methylphenyl)ethanone (35) are dissolved in 30 ml of dimethylformamide, and 4.0 ml (33.7 mmol) of benzyl bromide and 13.8 g (100 mmol) of potassium carbonate are added. The reaction mixture is stirred at room temperature for 3 hours. This is followed by addition of water and extraction twice with ethyl acetate. The combined organic phases are washed with saturated sodium chloride solution, dried over sodium sulfate and concentrated in a rotary evaporator. 1.35 g (40%) of compound 36 are obtained as a colorless crystalline product. C23H22O3 (346.2) MS (ESI+): 347.15 (M+H+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07288528B2 |
| 출처 데이터셋 | uspto-grants-2007_10 |
| ORD ID | ord-8db692d3984a417d809066e3c39e735c |
| 출처 메모 | uspto-grants-2007_10 |