Hydroxyamine hydrochloride → HCID 23072466, 화합물

HRID 1182471노트

반응식

HRID 1182471 반응식
[C:1]1([C:11]([CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH2:18][C:19]([OH:21])=O)=[O:12])[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1.[NH2:22][OH:23].Cl>C(N(CC)CC)C>[OH:23][NH:22][C:19](=[O:21])[CH2:18][CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][C:11]([C:1]1[C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=[CH:3][CH:2]=1)=[O:12]

참가 물질

4

반응물 2

HCID 443297Hydroxyamine hydrochlorideHCID 230724738-(1-Naphthyl)-8-oxooctanoic acid

생성물 1

HCID 23072466HCID 23072466, 화합물수율 58%

시약·촉매·용매 1

HCID 8471Triethylamine용매

실험 절차

Following the procedure described in Example 14, step 3, but substituting carboxylic acid 50f for 37 and using 1.1 equivalent of NH2OH.HCl and triethylamine each, the title compound was obtained as light yellow solid in 58% yield: 1H NMR (300 MHz, CD3OD/CDCl3=5/1) δ 8.50 (d, J=8.1 Hz, 1H), 7.40-7.90 (m, 6H), 2.93(t, J=7.5 Hz, 2H), 2.12 (m, 2H), 1.69 (m, 2H), 1.59 (m, 2H), 1.30 (m, 4H); 13C NMR (75.4 MHz, CD3OD/CDCl3=5/1) δ 24.27, 25.08, 28.63(2), 32.65, 41.88, 124.29, 125.53, 126.27, 127.33, 127.70, 128.30, 129.91, 132.32, 133.77, 135.91, 171.87, 205.28.

출처 및 근거

ORD 기록
ord-57fe9b414660430e917dad20c1c5681b
출처 데이터셋
uspto-grants-2007_10
특허 번호
US07288567B2

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