Potassium Carbonate → HCID 66864166, 화합물
반응식
[Br:1][C:2]1[C:3](F)=[C:4]([CH:7]=[CH:8][CH:9]=1)[C:5]#[N:6].Cl.[NH2:12][CH2:13][C:14]([NH2:16])=[O:15].C([O-])([O-])=O.[K+].[K+]>CS(C)=O>[Br:1][C:2]1[CH:9]=[CH:8][CH:7]=[C:4]([C:5]#[N:6])[C:3]=1[NH:12][CH2:13][C:14]([NH2:16])=[O:15]참가 물질
5
반응 조건
- 온도
- 100 °C
실험 절차
10.0 g (50.0 mmol) 3-bromo-2-fluorobenzonitrile, 11.1 g (100.0 mmol) glycinamide hydrochloride and 17.3 g (125 mmol) K2CO3 were suspended in 90 ml DMSO and heated at 100° C. for 4 h. Having cooled down to room temperature, the solvent was concentrated and water was added. The resulting precipitate was sucked off and washed with water. 10.8 g (85%) 2-(2-bromo-6-cyano-phenylamino)acetamide was obtained. ESI-MS [m/z]: 254, 256 [M+H]+
후처리
- temperatureHaving cooled down to room temperature
- concentrationthe solvent was concentrated
- additionwater was added
- washwashed with water
출처 및 근거
- ORD 기록
- ord-50fb28455ce242dc825b93781f50cab8
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08664233B2
반응 노트
불러오는 중…