Ammonium Chloride → HCID 58118555, 화합물
반응식
[Na].[Br:2][C:3]1[CH:8]=[CH:7][CH:6]=[C:5]([C:9]#[N:10])[C:4]=1[NH:11][CH2:12][C:13]([NH2:15])=[O:14].[NH4+].[Cl-]>CC(O)C>[NH2:10][C:9]1[C:5]2[C:4](=[C:3]([Br:2])[CH:8]=[CH:7][CH:6]=2)[NH:11][C:12]=1[C:13]([NH2:15])=[O:14]참가 물질
5
반응 조건
- 온도
- 0 °C
실험 절차
1.17 g (50.9 mmol) sodium was dissolved in 150 ml 2-propanol. Then, 10.82 g (42.6 mmol) 2-(2-bromo-6-cyano-phenylamino)acetamide was added and the solution was refluxed for 15 min. Thereafter, the reaction mixture was cooled to 0° C. and saturated NH4Cl solution was added. The solvent was concentrated, the resulting precipitate was sucked off and washed with water. 8.6 g (79%) 3-amino-7-bromo-1H-indole-2-carboxylic acid amide was obtained. ESI-MS [m/z]: 254, 256 [M+H]+
후처리
- temperaturethe solution was refluxed for 15 min
- concentrationThe solvent was concentrated
- washwashed with water
출처 및 근거
- ORD 기록
- ord-9cb455f558d049af9bf991a3ddac2882
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08664233B2
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