Sodium borohydride → HCID 67362472, 화합물
반응식
[CH3:1][C:2]([CH3:35])([CH3:34])[C:3](=[O:33])[CH2:4][O:5][C:6]1[N:10]([C:11]2[CH:16]=[CH:15][CH:14]=[CH:13][C:12]=2[F:17])[N:9]=[C:8]([C:18]([NH:20][C@H:21]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[CH3:32])[CH2:22][C:23]([OH:25])=[O:24])=[O:19])[CH:7]=1.[BH4-].[Na+]>C(Cl)Cl>[F:17][C:12]1[CH:13]=[CH:14][CH:15]=[CH:16][C:11]=1[N:10]1[C:6]([O:5][CH2:4][CH:3]([OH:33])[C:2]([CH3:35])([CH3:34])[CH3:1])=[CH:7][C:8]([C:18]([NH:20][C@H:21]([C:26]2[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=2[CH3:32])[CH2:22][C:23]([OH:25])=[O:24])=[O:19])=[N:9]1참가 물질
4
실험 절차
50 mg (0.1 mmol) of (S)-3-{[5-(3,3-dimethyl-2-oxo-butoxy)-1-(2-fluoro-phenyl)-1H-pyrazole-3-carbonyl]-amino}-3-o-tolyl-propionic acid were dissolved in 5 ml of DCM and 0.05 mmol of sodium borohydride were added. The mixture was stirred at room temperature overnight. The solvent was removed in vacuo and the residue subjected to preparative HPLC to given 52% of the title compound.