Water → 4-(Bromomethyl)-1-methoxy-2-nitrobenzene

HRID 1183213

반응식

HRID 1183213 반응식
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([O:8][CH3:9])=[C:4]([N+:10]([O-:12])=[O:11])[CH:3]=1.[Br:13]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1.O>C(Cl)(Cl)(Cl)Cl>[CH3:9][O:8][C:5]1[CH:6]=[CH:7][C:2]([CH2:1][Br:13])=[CH:3][C:4]=1[N+:10]([O-:12])=[O:11]

참가 물질

6

반응물 4

HCID 962WaterHCID 7187Benzoyl PeroxideHCID 670581-Methoxy-4-methyl-2-nitrobenzeneHCID 67184N-bromobutanimide

생성물 1

HCID 115796484-(Bromomethyl)-1-methoxy-2-nitrobenzene수율 70%

시약·촉매·용매 1

HCID 5943Carbon Tetrachloride용매

실험 절차

A solution of 4-methyl-2-nitroanisole (25 mmol), N-bromosuccinimide (25 mmol) and benzoyl peroxide (2.5 mmol) in carbon tetrachloride (100 mL) was heated at reflux for 18 h. The heated mixture was then poured into water. A solid precipitate formed and was separated by filtration. The aqueous filtrate was extracted with carbon tetrachloride (3×50 mL). The extract was concentrated under reduced pressure to yield a solid product. The solid products (the filtered precipitate and product of evaporating the extract) were combined and recrystallized from ethyl acetate-hexane to yield 4-methoxy-3-nitro benzyl bromide as a crystalline product in 70-75% yield. m.p. 110-112° C.

후처리

  1. temperatureat reflux for 18 h
  2. customA solid precipitate formed
  3. customwas separated by filtration
  4. extractionThe aqueous filtrate was extracted with carbon tetrachloride (3×50 mL)
  5. concentrationThe extract was concentrated under reduced pressure
  6. customto yield a solid product
  7. customThe solid products (the filtered precipitate and product of evaporating the
  8. extractionextract)
  9. customrecrystallized from ethyl acetate-hexane

출처 및 근거

ORD 기록
ord-6c1e7cac7cfe41c580b9d405893b910a
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08664272B2

연결된 노트

불러오는 중…