Diethylamine → H-Orn(Z)-OH

HRID 11838

반응식

HRID 11838 반응식
C([NH:18][C@H:19]([C:34]([OH:36])=[O:35])[CH2:20][CH2:21][CH2:22][NH:23][C:24]([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25])(OCC1C2C(=CC=CC=2)C2C1=CC=CC=2)=O.C(NCC)C>CN(C=O)C>[C:24]([NH:23][CH2:22][CH2:21][CH2:20][C@@H:19]([C:34]([OH:36])=[O:35])[NH2:18])([O:26][CH2:27][C:28]1[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=1)=[O:25]

참가 물질

4

반응물 2

HCID 8021DiethylamineHCID 14999635Fmoc-orn(Z)-OH

생성물 1

HCID 7009570H-Orn(Z)-OH수율 199.4%

시약·촉매·용매 1

HCID 6228Dimethylformamide용매

실험 절차

The compound obtained in Example 8-5 (122.8 mg) was dissolved in DMF (2.6 ml). After the addition of diethylamine (0.26 ml), the mixture was stirred for 2 hours at room temperature. After the reaction, the solvent was removed by distillation under reduced pressure and the residue was dried under vacuum to obtain the title compound (133.5 mg).

후처리

  1. customAfter the reaction
  2. customthe solvent was removed by distillation under reduced pressure
  3. customthe residue was dried under vacuum

출처 및 근거

ORD 기록
ord-5fa1bf7313374de8b97081467abfed33
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098215B2

연결된 노트

불러오는 중…