2-Pyridinemethanamine → Methyl 4-(2-(2-picolylamino)ethyl)benzoate

HRID 11841

반응식

HRID 11841 반응식
[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH2:8].C(N(C(C)C)CC)(C)C.Br[CH2:19][CH2:20][C:21]1[CH:30]=[CH:29][C:24]([C:25]([O:27][CH3:28])=[O:26])=[CH:23][CH:22]=1>C1(C)C=CC=CC=1>[N:1]1[CH:6]=[CH:5][CH:4]=[CH:3][C:2]=1[CH2:7][NH:8][CH2:19][CH2:20][C:21]1[CH:30]=[CH:29][C:24]([C:25]([O:27][CH3:28])=[O:26])=[CH:23][CH:22]=1

참가 물질

5

반응물 3

HCID 195092-PyridinemethanamineHCID 81531DiisopropylethylamineHCID 10586287Methyl 4-(2-bromoethyl)benzoate

생성물 1

HCID 21973687Methyl 4-(2-(2-picolylamino)ethyl)benzoate

시약·촉매·용매 1

HCID 1140Toluene용매2회

반응 조건

온도
80 °C

실험 절차

Commercially available 2-picolylamine (0.625 ml) was dissolved in toluene (15 ml) and diisopropylethylamine (0.715 ml) was added. After the addition of the compound obtained in Example 9-1 (499.7 mg), the mixture was stirred for two days at 80° C. After the reaction, toluene was added. The solution was washed with distilled water and saturated brine, and dried over anhydrous sodium sulfate. The solvent was removed by istillation under reduced pressure, and the residue was purified by silica gel column chromatography (25 g, chloroform/methanol=25/1) to obtain the title compound (400.1 mg) as light brown oil.

후처리

  1. additionwas added
  2. washThe solution was washed with distilled water and saturated brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. customThe solvent was removed by istillation under reduced pressure
  5. customthe residue was purified by silica gel column chromatography (25 g, chloroform/methanol=25/1)

출처 및 근거

ORD 기록
ord-a78758e5b0fc4b538301b9f611812224
출처 데이터셋
uspto-grants-2006_08
특허 번호
US07098215B2

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