Sodium Hydroxide → 2-Oxo-1,2-dihydrothieno[3,2-b]pyrazine-6-carboxylic acid
반응식
[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[C:9]([C:11]([O:13]C)=[O:12])[S:10][C:5]=2[N:4]=[CH:3]1.[OH-].[Na+]>CO>[O:1]=[C:2]1[NH:7][C:6]2[CH:8]=[C:9]([C:11]([OH:13])=[O:12])[S:10][C:5]=2[N:4]=[CH:3]1참가 물질
4
실험 절차
To a solution of methyl 2-oxo-1,2-dihydrothieno[3,2-b]pyrazine-6-carboxylate 21 (50 mg, 0.238 mmol) in methanol (3 mL) was added a solution of 2N sodium hydroxide (0.238 mL, 0.476 mmol). The reaction was stirred at rt for 2 h. Quenched with 2N HCl solution and extracted with EtOAc. Organic layer was washed with brine, dried and evaporated to give crude 2-oxo-1,2-dihydrothieno[3,2-b]pyrazine-6-carboxylic acid 84 (27 mg, 57%).
후처리
- customQuenched with 2N HCl solution
- extractionextracted with EtOAc
- washOrganic layer was washed with brine
- customdried
- customevaporated
출처 및 근거
- ORD 기록
- ord-5223ab19b26b4888b3501df6d5745985
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08669256B2
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