Water → 3-Ethoxythieno[2,3-b]pyrazine-6-carboxylic acid
반응식
Cl[C:2]1[N:7]=[C:6]2[S:8][C:9]([C:11]([O:13]C)=[O:12])=[CH:10][C:5]2=[N:4][CH:3]=1.[OH-].[Na+].O.C1C[O:21][CH2:20][CH2:19]1>CO>[CH2:20]([O:21][C:2]1[N:7]=[C:6]2[S:8][C:9]([C:11]([OH:13])=[O:12])=[CH:10][C:5]2=[N:4][CH:3]=1)[CH3:19]참가 물질
6
실험 절차
To a solution of methyl 3-chlorothieno[2,3-b]pyrazine-6-carboxylate 92 (0.044 mmol, 10 mg) in methanol 250 uL and THF 250 uL was added sodium hydroxide 2N in water (0.219 mmol, 109 μA) and stirred overnight at rt. The reaction mixture was quenched in 2N HCl and extracted with CH2Cl2/methanol (9/1). The organic layer was dried and concentrated under reduced pressure to give 3-ethoxythieno[2,3-b]pyrazine-6-carboxylic acid 97 (9.3 mg, 100%).
후처리
- customThe reaction mixture was quenched in 2N HCl
- extractionextracted with CH2Cl2/methanol (9/1)
- customThe organic layer was dried
- concentrationconcentrated under reduced pressure
출처 및 근거
- ORD 기록
- ord-57acba7d6d4b4dd6a83c3f0e9bd0900d
- 출처 데이터셋
- uspto-grants-2014_03
- 특허 번호
- US08669256B2
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