Hydrochloric Acid → Ethyl 2-(furan-2-yl)quinoline-4-carboxylate

HRID 1185438노트

반응식

HRID 1185438 반응식
Cl.[O:2]1[CH:6]=[CH:5][CH:4]=[C:3]1[C:7]1[CH:16]=[C:15]([C:17]([OH:19])=[O:18])[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=1.[C:20]1(C)C=CC=C[CH:21]=1>C(O)C>[CH2:20]([O:18][C:17]([C:15]1[C:14]2[C:9](=[CH:10][CH:11]=[CH:12][CH:13]=2)[N:8]=[C:7]([C:3]2[O:2][CH:6]=[CH:5][CH:4]=2)[CH:16]=1)=[O:19])[CH3:21]

참가 물질

5

반응물 3

HCID 313Hydrochloric AcidHCID 1140TolueneHCID 6976402-(Furan-2-yl)quinoline-4-carboxylic acid

생성물 1

HCID 27000068Ethyl 2-(furan-2-yl)quinoline-4-carboxylate

시약·촉매·용매 1

HCID 702Ethanol용매

실험 절차

To 40 ml of a saturated solution of hydrochloric acid in ethanol 2 g of 2-Furan-2-yl-quinoline-4-carboxylic acid was added and the mixture was heated to reflux for 3 h. Then, after cooling to RT, 30 ml of toluene was added and the solvents were removed under reduced pressure. The obtained crude product was pure enough for the next reaction step. Yield: 2.5 g.

후처리

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 3 h
  3. customthe solvents were removed under reduced pressure
  4. customThe obtained crude product
  5. customwas pure enough for the next reaction step

출처 및 근거

ORD 기록
ord-d5671b8c2b414fc28a2b84e0a9f1bd62
출처 데이터셋
uspto-grants-2014_03
특허 번호
US08669266B2

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